Enzymtechnologie

The use of catalysts, and particularly of their biological version (enzymes), has recently been the subject of increased debate in research, technology and environmental policy. Enzyme technology is regarded as a key technology for a sustainable future; it renders possible the manufacturing of innovative products (e.g. pharmaceuticals, fine chemicals, flavors, food and feed ingredients) and opens new doors for the application of biological agents in chemical processes, which leads to positive environmental effects and energy savings. Enzyme technology has a great potential for breaking down the boundaries between individual scientific disciplines (biotechnology, chemistry, microbiology, etc.) and between fundamental and applied research. Aims of this teaching unit are - to provide a basic knowledge of relevant protein structures, to acquire an understanding of the principles by which enzymes catalyse biochemical reactions, and - to provide a comprehensive overview of enzyme applications to introduce economic and sustainable goals associated with enzyme technologies, historical background and modern approaches of enzyme application (e.g. nanobiotechnology, biofuels, protein production, extremophiles, biopharmaceutical production, microbial natural products). For students the lecture and seminar will provide an understanding of scientific principles and will provide practice of advanced white biotechnology (professional competences) and its exploitation in commercial practice (methodic competences) for get individual orientation skills e.g. concerning an career as scientist, PhD studend or to understand how to create and manage a biotech business).

• Requirements: Successful participation at the seminar including a 30 min presentation and 15 min discussion.
• Final written examination (120 min)

• Hofrichter, M., K. Esser, The Mycota: Industrial Applications, 2010, Springer-Verlag Berlin Heidelberg
• Fessner, W., Anthonsen, T.: Modern Biocatalysis, 2008, Wiley-VCH, Weinheim
• Illanes, A.: Enzyme Biocatalysis, Principles and Application, 2008, Springer
• Liese, A., Seelbach, K., Wandrey, C, Industrial Biotransformations, 2006, Wiley-VCH, Weinheim
• Buchholz, K., Kasche, V., Bornscheuer, U. T., Biocatalysts and Enzyme Technology, 2005, Wiley-VCH, Weinheim
• Bommarius, A.S., Riebel, B.R.: Biocatalysis, Fundamentals & Application, 2004, Wiley-VCH, Weinheim
• Aehle, W., Enzymes in Industry, 2004, Wiley-VCH, Weinheim
• Kiebist, J., Schmidtke, K.-U., Zimmermann, J., Kellner, H., Jemlich, N., Ulrich, R., Zänder, D., Hofrichter, M. & Scheibner, K. (2017). A peroxygenase from Chaetomium globosum catalyzes the selective oxygenation of testosterone. ChemBioChem, Vol. 18: 563-569 (doi: 10.1002/cbic.201600677).
• Olmedo, A., Aranda, C., del Rio, J. C., Kiebist, J., Scheibner, K., Martínez, A. T. & Gutiérrez, A. (2016). From Alkanes to Carboxylic Acids: Terminal Oxygenation by a Fungal Peroxygenase. Angewandte Chemie International Edition, Vol. 55(40): 12248-51 (doi: 10.1002/anie.201605430).
• Kiebist, J., Holla, W., Heidrich J., Poraj-Kobielska, M., Sandvoss, M., Simonis, R., Gröbe, G., Atzrodt, J., Hofrichter, M. & Scheibner, K. (2015). One-pot synthesis of Human Metabolites of SAR548304 by fungal peroxygenases. Bioorganic & Medicinal Chemistry, Vol. 23(15): 4324-32 (doi:10.1016/j.bmc.2015.06.035)

The module is only offered in the winter semester

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