Vorlesung
2 SemesterwochenstundenBTU-Vorlesungsverzeichnis ↗- Donnerstag08 Okt 2026 bis 28 Jan 202708:00 bis 09:30
Ausfälle und Änderungen
- 17.12.2026: MHB
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14333Fakultät 2 – Umwelt und Naturwissenschaften
Aufarbeitung von Produkten der Industriellen Mikrobiologie
Titel auf Englisch: Downstream Processing for Products of Industrial Microbiology
Lernergebnisse
- Lecture: familiarization with industrial applications of processing methods for microbial products to gain an overview; understanding the relationships between material properties and methods of enrichment; recognizing the advantages and disadvantages of different separation methods; understanding the causes of economic successes and failures
- Seminar: practicing presentation and scientific discussion, i.e. logical and factual argumentation using appropriate technical language, concentrating on the essentials and dealing fairly with discussion partners. Seminar: Practicing presentation and scientific discussion, i.e. logical, factual argumentation in appropriate technical language, concentration on the essentials and fair treatment of discussion partners; developing a critical attitude towards experiments, results and conclusions; independent development of important connections from review articles and original papers …
Inhalte
- Lecture:
- The lecture deals with the recovery and purification of biotechnical products to achieve the desired specification while maximizing yield and minimizing process costs. Often down-stream processing is the most expensive part of the stream.
- The focus is firstly on sedimentation of cells and solid particles as well as on alternatives like flocculation and flotation, filtration and centrifugation. Disintegration techniques are discussed. Product isolation by extraction or sorption is a further chapter. Furthermore precipitation and chromatography as well as membrane separation, e.g. reverse osmosis or ultrafiltration, are interesting topics. Electrophoresis and drying are closing the separate discussion of single methods. After-wards combined operations are explained. A special chapter is the refolding of proteins, which have to gain function, e.g. enzymatic activity, after, e.g. production as inclusion bodies.
- Several examples show economic solutions: commercial enzymes, recombinant proteins, polysaccharides, antibiotics, organic acids, ethanol, and biomass.
- Seminar:
- Self-study of original publications, reviews and patents; presentation of a table or a figure with measurement data or scientific models; critical discussion of the data; comparison of the methods presented with alternative methods; discussion of the strengths and weaknesses of selected models
Voraussetzungen
Verpflichtende Voraussetzungen
Keine
Empfohlene Voraussetzungen
Basic knowledge of physics, chemistry, organic chemistry, biochemistry, molecular biology, microbiology, cell biology
Prüfungsmodalitäten
Written exam graded 120 min
Termine im WiSe 26/27
Seminar
1 SemesterwochenstundeBTU-Vorlesungsverzeichnis ↗- Dienstag13 Okt 2026 bis 26 Jan 202714:30 bis 16:00
Prüfung
BTU-Vorlesungsverzeichnis ↗- Dienstag09 Mär 202710:00 bis 12:00
Angeboten in
- Chemistry: Materials, Engineering and SustainabilityMaster
Wahlpflichtkomplex: Kein Komplex genannt
| Studiengang | Abschluss | Wahlpflichtkomplex |
|---|---|---|
| Chemistry: Materials, Engineering and Sustainability | Master | Kein Komplex genannt |
Literatur und Materialien
Textbooks: Wilson DB, Sahm H, Stahmann KP, Koffas M (2020) Industrial Microbiology, Wiley-VCH, Weinheim Jagschies, G., Lindskog, E., Lacki, K., & Galliher, P. M. (Eds.). (2018). Biopharmaceutical processing: development, design, and implementation of manufacturing processes . Elsevier. Selected reviews, e.g. Hohmann HP, Stahmann KP (2010) Comprehensive Natural Products II. Chemistry and Biology, 10, 115-139. Jungbauer, A. (2013). Continuous downstream processing of biopharmaceuticals. Trends in biotechnology , 31 (8), 479-492. Nunes, D. D., Pillay, V. L., Van Rensburg, E., & Pott, R. W. M. (2024). Oleaginous microorganisms as a sustainable oil source with a focus on downstream processing and cost-lowering production strategies: A review. Bioresource Technology Reports , 101871.
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